First ‘Three-Parent DNA’ Babies Born Healthy

Eight children have been born in the United Kingdom (UK) using the DNA of three individuals, in a groundbreaking attempt to prevent inherited mitochondrial diseases.

The technique, known as mitochondrial donation, involved combining DNA from the biological parents with healthy mitochondria from a female donor.

Mitochondria, the energy producers within cells, carry their own genetic material and are inherited exclusively from mothers. Faulty mitochondria can cause severe health conditions, including muscle weakness, organ failure and neurological damage.

Scientists at Newcastle University pioneered the method’s development, with each case requiring approval from the UK fertility regulator. So far, 35 patients have been approved, and one pregnancy is ongoing. The eight children, including a pair of twins, are reportedly healthy and developing normally.

Professor Doug Turnbull, head of the research project, described it as “a big step forward”, while developmental biologist Robin Lovell-Badge noted the donor DNA makes up “less than 1%” and does not influence the child’s traits.

While hailed as a scientific milestone, the procedure has drawn ethical debate, particularly regarding potential heritable genetic changes. Nonetheless, for families affected by devastating mitochondrial disorders, the technique offers new hope for having healthy, genetically related children.

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